Flexeril (Cyclobenzaprine Hcl)

Flexeril Review

Flexeril is a muscle relaxant, used to treat the pain and stiffness of muscle injuries, including strains, sprains and muscle spasms. The active ingredient in Flexeril is cyclobenzaprine.

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Flexeril Drug Class and Mechanism

Cyclobenzaprine and another similar muscle relaxant trazadone are structurally related to the first-generation tricyclic antidepressants such as imipramine. It therefore should not be used within 14 days of cessation of therapy with monoamine oxidase inhibitors (MAOIs). The exact mechanism of action for cyclobenzaprine is unknown. Current research appears to indicate that cyclobenzaprine acts on the locus coeruleus where it results in increased norepinephrine release, potentially through the gamma fibers which innervate and inhibit the alpha motor neurons in the ventral horn of the spinal cord.Decreased firing of the alpha motor neuron results

Flexeril Uses

Flexeril relaxes muscles and relieves pain and discomfort associated with strains, sprains, spasms or other muscle injuries.May be taken with food if stomach upset occurs. Take this medication as directed. Do not increase your dose or take it more often than prescribed.

Flexeril Side Effects

May cause stomach upset, heartburn, constipation, headache, dizziness or drowsiness or dry mouth the first few days as your body adjusts to the medication. If these symptoms persist or become severe, notify your doctor. Inform your doctor if you develop: muscle stiffness, skin rash, itching, rapid heart rate, swelling of the face, difficulty urinating. When rising quickly from a sitting or lying position, dizziness or lightheadedness may occur. Change positions slowly and use caution on stairs. Avoid activities requiring alertness if dizziness or drowsiness occurs. If you notice other effects not listed above, contact your doctor or pharmacist.

Flexeril Pregnancy

Flexeril Overdose

Although rare, deaths may occur from overdosage with FLEXERIL. Multiple drug ingestion (including alcohol) is common in deliberate cyclobenzaprine overdose. As management of overdose is complex and changing, it is recommended that the physician contact a poison control center for current information on treatment.Signs and symptoms of toxicity may develop rapidly after cyclobenzaprine overdose; therefore, hospital monitoring is required as soon as possible. The acute oral LD50 of FLEXERIL is approximately 338 and 425 mg/kg in mice and rats, respectively.

Flexeril More Information

Flexeril may enhance the effects of alcohol, barbiturates, and other CNS depressants.